- These work by raising the levels of the chemicals serotonin and noradrenaline in the brain, which both tend to elevate the mood.
- Tryptophan is an amino acid that serves as a precursor to the neurotransmitter serotonin.
- Both serotonin and noradrenaline are activated in the brain by anxiety-inducing circumstances.
- There is some evidence of that the neurotransmitter serotonin may play a role in this disorder.
- These physiological changes decrease patients' pain thresholds and thereby increase pain sensation, anxiety, fear, and the release of pain transmitters, such as histamines, serotonins, kinins, and prostaglandins.